Abstract: As the rise of chemistry, biology, new materials and other industries, the role of science to innovation becomes increasingly significant. This paper is to analyze science-based innovation by using the cases from the Nobel Prize achievements. The results show that, the proportion of commercialized Nobel Prize sciences was increased by decades. Since 2000, there are fourteen Nobel Prize achievements have been commercialized. 51.2% of scientific discovery was born in the University, 17.61% of scientific discovery was born in public institutions. On average, there are 17.61 years from scientific discovery to commercialize. At last, we refined three science-based innovation model. Model one is “enterprises dominant the innovation”; Model two is “both enterprises and university or public institutions participate in the innovation”; Model three is “the spin-off participate in the innovation”.