Abstract: The paper based on the theory of human capital and industrial cluster, collecting China nearly a decade high technology industry and high-tech talent panel data, calculated the high-tech talent and high technology industry location quotient of 29 provinces and cities, using STATA12.0 analyzed high-tech talents and other various factors that maybe impact on high technology industry agglomeration. The results showed that influence each other between talent agglomeration and industry cluster, openness, policy, transportation and other factors on the different regional high-tech industry agglomeration exert different influence; Also found that the eastern region of high-tech talent agglomeration degree is high, the high technology industry development is good, the central region, west of Shanxi province is the only one belongs to talent agglomeration and industry cluster is to enter the top ten provinces in the country.