Abstract: An orderly mobility of talents in science and technology think tanks helps to enhance the research level and steady development of think tank institutions. This paper analyzes the personal resume information of 551 talents in science and technology think tanks in China based on CV (Curriculum Vitae) analysis method, carrying out a study on the scale, mobility paths and characteristics of science and technology think tank talents with career mobility experiences. Furthermore, Poisson regression and logistic regression are applied to figure out mobility influencing factors. It is found that there exist certain barriers to the mobility between different types, and science and technology think tank talents with career mobility experiences overall show a tendency to flow to public service units; in terms of mobility paths, there show a trend of eastward flow, manifesting as the majority conducting intra-city mobility in the eastern regions while the majority of inter-provincial mobility towards eastern regions in others; in terms of mobility frequency, the younger the career age is at the time of the first mobility, the more career mobility occurs afterwards; 6.72% of the talents in science and technology think tank talents have “Revolving Door” mobility experience, and it is further found that there is a positive correlation between the probability of “Revolving Door” mobility and the number of career mobility.