Abstract: This paper undertakes a systematic review and theoretical synthesis of the mechanisms through which Pasteur-type scientists engage in and catalyze industry-university collaboration (IUC). Moving beyond theoretical exposition, the research is empirically grounded in the practical model of Industry-University Collaborative R&D Centers, a policy-driven initiative prominently adopted by small and medium-sized enterprises (SMEs) within Hubei Province, China. The methodological approach combines a review of extant literature with rich, qualitative data derived from semi-structured interviews conducted with administrators and principal investigators at twelve distinct such centers. This robust methodological foundation enables the construction of a novel, multi-level incentive theory that explicates the drivers of Pasteurian scientific engagement within the complex socio-economic framework of IUC. The theoretical model pivots on two central pillars: the indispensable, agency-like role of the Pasteur-type scientist as a bridge between fundamental inquiry and applied commercial development, and the critical importance of institutional incentive structures designed to augment the innovative output of these partnerships. Quantitative analysis conducted as part of this study yields a compelling finding: collaborative ventures that actively involve Pasteur-type scientists demonstrate a statistically significant enhancement in patent output, with an average increase of 3.512 patents compared to those that do not feature such pivotal figures. This finding underscores the scientist's role not merely as a participant but as a fundamental multiplier of innovation productivity. Delving deeper into the institutional enablers, the theory posits and validates several key moderating factors. Firstly, the organizational transformation of the academic institution itself is paramount. When the host university of a Pasteur-type scientist consciously evolves towards an "entrepreneurial university" model, it institutionalizes support structures that are critical for success. Crucially, this shift involves the implementation of equitable research assessment and evaluation systems that recognize and reward applied research, patent filings, and knowledge transfer activities on par with traditional academic publications. This institutional legitimacy removes a significant barrier to scientist participation and directly correlates with greater collaborative output. Secondly, the micro-level design of the collaboration contract is identified as a direct motivational lever. Agreements that stipulate transparent, equitable, and forward-looking clauses regarding intellectual property (IP) ownership and the sharing of long-term profits/revenues serve as powerful ex-ante incentives. By ensuring that Pasteur-type scientists are not merely compensated for their time but are also granted a stake in the future commercial success stemming from their ingenuity, these contracts align the interests of the individual researcher with the broader objectives of the collaboration, thereby fostering deeper commitment and yielding superior innovation performance. Finally, the macro-level role of government and external stakeholders is emphasized. The research finds that proactive support from local governments, manifested through higher direct subsidies for IUC projects, acts as a crucial risk-mitigating catalyst. Furthermore, government agencies can perform a vital brokerage function by facilitating introductions and attracting greater volumes of social capital and venture funding into these partnerships. This injection of financial and network resources expands the operational scale and ambition of the R&D centers, creating a more fertile environment for the generation of marketable technologies and thus leading to a higher volume of tangible outcomes.