Abstract: The business environment and industrial transfer and undertaking are important factors that regulate the high-quality development of a region. This article conducts a survey on 9 provinces (3 each in the eastern, central, and western regions) and 32 cities (7 provincial capitals and 25 prefecture level cities) in the eastern, central, and western regions of China. Based on literature data such as the Statistical Yearbook and Statistical Abstract from 2006 to 2024, 2998 survey samples were combined for interactive correlation analysis and regression analysis, which to some extent analyzes and presents the inherent connections between the three. Research has found that the business environment has a significant positive impact on regional high-quality development, and industrial transfer has a significant effect on the relationship between the business environment and regional high-quality development. There are differences and discrete characteristics in different regions, industry types, and development categories. Therefore, it is necessary to create a more accurate, scientific and systematic business environment, build a regional industrial development plan with orderly gradient transfer and reasonable echelon development, so as to promote the regional high-quality development of difference, coordination and sustainability, and accelerate the development process of Chinese path to modernization.