Abstract: General-purpose technologies and technology transfer in universities is a crucial way to overcome the bottleneck of being "stuck" by core technologies and to address the disconnection between innovation chain and industrial chain. Technology transfer in universities is not only a bridge that connect scientific research and production, but also a core driving force to promote high-quality development. However, in this process, a series of challenges occur, including technology islands, lack of market orientation and capital. To search for solutions, relevant studies usually focus on the process of technology transfer, demonstrating that it is affected by internal and external factors, such as the capabilities of R&D practices, policy regulation, academic entrepreneurship activities, etc. These studies also investigate the channels to realize technology transfer, including patent licensing, the establishment of spin-of and U-I innovation collaboration. Unfortunately, these studies often neglect the inherent nature of technological emergence in universities: 1) the technical characteristics of the endogenous emergence of universities; 2) the internal mechanism of how universities utilize knowledge reorganization via general-purpose technologies to realize efficient technology transfer. To fill above research gaps and enrich current studies on university technology transfer, this paper investigates how universities reorganize knowledge through general-purpose technologies, and the intrinsic mechanisms enabling them to bridge both the "subject" and "domain" gaps in technology transfer from knowledge reorganization perspective. To empirically verifies above hypotheses, we obtain information of 72,944 patents from 284 Chinese universities from IncoPat database, then using the Logit model to perform estimation. We find that: (1) Different university general-purpose technologies vary in their transfer—higher applied generality of university technologies increases the likelihood of technology transfer, while higher basic generality decreases this likelihood. (2) Government subsidies enhance the relationship between applied generality of university technologies and technology transfer but weaken the relationship between basic generality and technology transfer. (3) The maturity of knowledge enhances the relationship between applied generality of university technology and technology transfer, without significant moderating effect on the relationship between basic generality and technology transfer. This study decomposes a unique attribute (generality) of university technology from an endogenous perspective, thereby enriching the research on the relationship between general-purpose technology and technology transfer, so that providing insights for universities to achieve "double-leap". Our contributions are twofold: (1) rather than macro and exogenous theoretical perspectives. we investigate technology transfer from a micro perspective of "general-purpose technology", which enriches the research on the micro mechanism of the technology transfer in universities. (2) we introduce the knowledge reorganization theory to explore internal mechanism of "subject" and "domain" double gap in university technology transfer, so that effectively promoted the new understanding of the technology transfer in universities. (3) we empirically examine the moderating role of government subsidies and knowledge maturity, which reveals the influencing mechanism of external factors on universities’ technology transfer and enriches the studies on innovation policy and knowledge management. This study provides practical implications as well. First, universities should build an interdisciplinary research platform to deeply integrate fundamental theories and practical knowledge, bridge social needs and technological frontiers, and improve the efficiency and quality of knowledge reorganization. Second, based on effective knowledge reorganization, universities should actively seek and deepen tripartite collaboration (university-industry-government) to accelerate their technology output and transfer. Third, government should facilitate university-industry cooperation by building a platform for information exchange and resource sharing, which accelerates technology transfer; meanwhile, policy instruments could be used to encourage and support innovative and practical research in universities, realizing the self-reliance on science and technology development.