Abstract: Responsible Research and Innovation (RRI), as a global value, is gradually expanding from the framework dominated by the Global North to a widely accepted international consensus. However, despite the increasing recognition of RRI’s core principles by more countries, its path toward global implementation still faces numerous challenges. These challenges stem not only from cross-cultural and cross-institutional heterogeneity but also from the impacts of dramatic changes in global geopolitics and the rise of nationalism, which have led to the increasing phenomenon of ethical dumping. This paper explores, from theoretical, historical, and practical perspectives, how RRI can transcend the technology governance model constructed by Global North countries and form a framework that is more globally adaptable. Through this exploration, the paper aims to prevent RRI from becoming a casualty of political maneuvering and contribute to the creation of a more equitable and inclusive global science governance system.