Abstract: Knowledge fusion transformation (KFT) is the practice of cognitive agent’s complexity thinking based on multi-cognitive strategies in solving complex problems. In order to establish a more perfect collaborative innovation mechanism for solving the complex problems satisfactorily, KFT should adopt the integrated multi-cognitive strategies that take on "system" thinking as its basis, "life" metaphor as its basic form, "ecological" metaphor as its basic guarantee according to its connotation, characteristics，the need for multilateral collaborative innovation by following the basic feature of “non-machine” metaphor cognition; On methodological level, it also necessarily choose the integrated multi-cognitive approach that take on holism method as its guidance, new reduction cognitive methods as its specific means, network cognitive methods as its deepen way. Aimed at the simplicity thinking formed by "machine" metaphor cognitive, the multi-cognitive approach based on the cognitive agent’s sense accommodative organs, knowing and doing interactive organs integrated synthetically, can make the cognitive agent self-fulfill KFT by upward causality and downward causality, finally ensure that the complex problems are solved with collaborative innovation.