Abstract: With the coordinated promotion of digital industrialization and industrial digitization, digital transformation continues to reshape the development process of traditional industries in China and has become an important driving force for building the resilience of manufacturing industry chain. This article empirically explores the impact of digital transformation on the resilience of manufacturing industry chain using the spatial Durbin model. The results show that digital transformation significantly enhances the resilience of the local manufacturing industry chain, but has a certain negative effect on neighboring regions, and the talent aggregation and the technological innovation play a mediating role in the relationship between the digital transformation and the resilience of the manufacturing industry chain. Heterogeneity analysis shows that digital transformation in the eastern and central regions has a significant promoting effect on the resilience of local manufacturing industry chains, and has a siphon effect on neighboring regions. But the digital transformation in the western region has a positive impact on the resilience of both local and neighboring manufacturing industry chains. Further analysis reveals that the digital transformation of the overall country has the most significant impact on the innovation dimension of the resilience of the manufacturing industry chain, and there are significant differences in the impact of digital transformation on the resilience dimensions of the manufacturing industry chain in different regions. The conclusion of this paper provides strong reference for accelerating the integration of digital economy and real economy and helping to enhance the resilience of manufacturing industry chain.